Extracellular Vesicles (EVs) – Exosomes
Secretomes or Extracellular Vesicles (EVs) with Growth Factors and mRNA
Extracellular Vesicles (EVs) or Secretomes are isolated from Placental Mesenchymal Stem Cell (pMSCs)
What Are EVs
EVs or Secretomes are nanoparticles that are released and received by nearly all cells in the body. They are typically 30-100 nm in size. These extracellular vesicles act as one of our body’s communication systems, delivering important molecular payloads from cell to cell. Each EV’s particular biological function is determined by molecules that reside either on its surface or in its interior.
Exosomes vs Secretomes
EVs are sometimes called exosomes or Secretomes. They produced by signaling cells (some of which are Mesenchymal Stem Cells) upon specific physiological or environmental cues, which contain a precision payload capable of modulating the phenotype of target cells.
Early findings suggest that MSC-derived exosomes or Secretomes can modulate the phenotype of macrophages. This is the likely Mechanism of Action that EVs exert on inflammation, since macrophages play a pivotal role in regulating immune responses.
Mechanism of Action
Secretomes seek out specific cellular targets and, upon arriving at their intended destination, can transfer their cargo of mRNA, miRNA, and growth factors to recipient cells or activate signaling pathways in order to change the behavior of the recipient cell.